A-PPP. α-Pyrrolidinopropiophenone (α-PPP) is a new designer drug with assumed amphetamine-like effects which has appeared on the illicit drug market. It is similar in structure to the appetite suppressant diethylpropion and has analogous effects in animals. Little is known about this compound, but it has been detected by laboratories in Germany as an ingredient in “ecstasy” tablets seized by law enforcement authorities. This drug has been found to produce stimulant effects in animals and presumably also produces these effects in humans, based on the context in which it has been found. This product is intended for forensic and research applications.
A-PPP is illegal in the UK under the blanket ban on substituted cathinones, and due to its structural similarity to illegal drugs such as methcathinone and pyrovalerone it might be considered a controlled substance analogue in some countries such as the USA, Australia and New Zealand. Analogues of A-PPP such as pyrovalerone and MDPV have been more widely used and are presumed to be more potent and addictive than A-PPP itself. Structure-activity relationships of these drugs suggest that a variety of ring-substituted analogues are likely to be potential drugs of abuse, and stimulant activity has been found for analogues with between 3 and 6 carbon atoms in the alkyl chain.
Its official designation in the IUPAC system is defined:1-phenyl-2-(1-pyrrolidinyl)-1-propanone , and simple chemical formula of the substance is summed up as C13H17NO , with the molecular weight determined to be 239.7 g/mol.
On-line, ALPHA-PPP is suplied as a crystalline solid.A stock solution may be made by dissolving the ALPHA-PPPin the solvent of choice.ALPHA-PPP is soluble in organic solvents such as ethanol,DMSO, and dimethylformamide, which should be purge with a inert gas. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments.Ensure that the residual amount of organic solvent is insignificant,since organic solventhave physiological effects at low concentrations.Organic solvent-free aqueous solutions of ALPHA-PPP can be prepared by directly dissolving the crystalline solid in aqueous buffers. It is not recommended storing the aqueous solution for more than one day.
The desired effects of ALPHA-PPP are euphoria, rush, alertness, talkativeness, sexual arousal, focused mind and an overall positive feeling. The effects occur within 30 to 45 min of administration and the desired effects last from 1 to 3 h; however, the undesirable side effects of ALPHA-PPP use can last from hours to days. The side effects are neurological and cardiovascular in nature and include the following: anxiety, insomnia, fatigue, mydriasis, agitation, aggression, combative behavior, panic, disorientation, confusion, memory loss, blackouts, myoclonus, excited delirium, paranoia, hallucinations, increased suicidal ideations, chest pain, tachycardia, breathing difficulties, hyperthermia, sweating and hypertension. Local hospital emergency room staff and first responders have reported that ALPHA-PPP users are often violent and uncontrollable, exhibiting paranoid behavior and delusions.
Unverified sources report :”Oral and nasal consumed can act mildly euphoric. It also leads to a suppression of hunger, thirst and fatigue and may in low to moderate doses (about 60-100 mg) increase the attention in the short term. If A-PPP is consumed i.v., it will quickly lead to an intense euphoric and anxiolytic effect. Side effects of overdoses are sweating, palpitations, and erectile difficulty. Compared to other amphetamines who activates the muscles of mastication , teeth grinding does not seem to be so strong.”